Cutaneous metastasis as a complication of hepatic intra-arterial chemotherapy.

A 44 year old man who had a resection for an adenocarcinoma of the tranverse colon was also found to have a metastatic nodule in the right lobe of the liver (segment VI). He underwent a laparotomy, during which an intra-operative ultrasound revealed 2 additional nodules in segments IV and VII. These three lesions were resected, each with 2 cm margin of normal liver. A Portacath (Pharmacia Deltic/NC, St Paul MN55112, USA) was inserted into the gastroduodenal artery. A regime ofhepatic intra-arterial chemotherapy was commenced post-operatively with seven doses of 5-Fluorouracil (5-FU) (500mg/M2 per day) and one dose of Mitomycin C (5mg/M2) on the first post-operative day. He was subsequently given seven cycles of 5-FU (400mg/M2 intravenous bolus followed by the same dose in an intravenous infusion over 18 hours on days 1 and 2 of the cycle) and folinic acid (200mg/M2 intravenous infusion, also on